The skirmishes between Christians and Muslims in Nigeria represent a persistent and complex challenge that has shaped the nation‘s sociopolitical landscape for decades. Rooted in historical, ethnic, economic, and political factors, these conflicts transcend mere religious differences. This study explores the nature, causes, and implications of Christian-Muslim skirmishes with particular attention to flashpoint regions such as the Middle Belt, Kaduna, Plateau, and parts of North-East. The work examines how colonial legacies, competition for land and political power, and mutual suspicion have contributed to recurring tensions between the two religious groups. It also highlights how extremist ideologies, economic marginalization, and the manipulation of religion by political actors escalate minor disagreement into violent confrontations. Furthermore, the research assesses the impact of these conflicts on national cohesion, economic development, intergroup relations, and the safety of lives and property. The displacement of communities, destruction of infrastructure, and erosion of trust between religious adherents are presented as significant consequences. The study alsoevaluatesgovernmentresponses,peacebuildin g initiatives, and the role of religious leaders in promoting reconciliation. It argues that sustainable peace requires inclusive dialogue, equitable distribution of resources, and deliberate efforts to address structural injustices.