Bundelkhand is one of the most climatevulnerable agro-ecological regions of Uttar Pradesh, characterized by erratic rainfall, frequent droughts, high temperature extremes, and fragile soils. These conditions severely constrain productivity of major crops such as wheat, rice, and maize. The present study synthesizes fieldbased evidence and regional experimental findings toevaluate physiological and biochemical responses of crops under individual and combined heat and drought stress conditions specific to Bundelkhand. Key physiological traits including photosyntheticperformance,stomatal conductance, canopy temperature, and relative water content were assessed alongside biochemical indicators such as proline accumulation, lipid peroxidation, and antioxidant enzyme activity. The study demonstrates that combined heat and drought stress causes disproportionately higher physiological impairment and oxidative damage compared to individual stresses, while stresstolerant genotypes exhibit enhanced osmotic adjustment and antioxidant defense. The findings provide a region-specific framework for crop improvement and climate-resilient agronomic strategies in Bundelkhand.